Zinc transporter ZIP8 Antibodies

AND SLC39A8 ELISA kits, Zinc transporter ZIP8 Proteins

Many biological assays use antibodies to detect Zinc transporter ZIP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter ZIP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter ZIP8 antibodies...

We validate the specificity of these antibodies to Zinc transporter ZIP8 by testing them on tissues known to express SLC39A8 positively and negatively. Browse below to find the SLC39A8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC39A8 Infographic by Boster Bio

All SLC39A8 Products

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Anti-ZIP8 SLC39A8 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A04007
0.1 mg

BIGM103 (SLC39A8) (NM_022154) Human Over-expression Lysate

Human

$628
Cat # LS064116
100 µg

SLC39A8 Overview

Facts about Zinc transporter ZIP8.

SLC39A8 3D structure. Source: alphafold

Zinc transporter ZIP8 (SLC39A8)

Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake to the brain (PubMed:26637978).

Gene Information

Human
Gene Name:	SLC39A8
Uniprot:	Q9C0K1
Entrez:	64116

Family

Belongs to:

ZIP transporter (TC 2.A.5) family

Alternative Names

BCG induced integral membrane protein BIGM103; BIGM103BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; zinc transporter ZIP8; ZIP8; ZIP-8; Zrt- and Irt-like protein 8

Molecular Weight

Mass (kDA):
49.631 kDA

Genomic Context


Human

Location:	4q24
Sequence:	4; NC_000004.12 (102251041..102345482, complement)

Tissue Specificity

Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Associated with the lysosomal/endosomal compartment following transfection.

Diseases

Inflammation
Testicular Necrosis
Fibrosis
Zinc Deficiency Disorder
Anemia
Kidney Failure
Cystic Fibrosis
Disease Of Adrenal Medulla
Overlying Behavior
Malaria, Falciparum
Lung Diseases
Coronary Artery Disease

Chronic Obstructive Airway Disease
Cardiovascular Diseases
Hemorrhage
Nervousness
Fanconi Syndrome
Retroviridae Infections
Malaria

Pathways

Transport
Localization
Cell Death
Secretion
Receptor-mediated Endocytosis
Cell Adhesion
Cell Activation
Cell Proliferation
Gastrulation
Dna Hypermethylation
Insulin Secretion
T Cell Activation
Tube Formation

Endocytosis
Demethylation
Chemotaxis
Antigen Processing And Presentation
Cell Cycle
Cell Differentiation
Organ Morphogenesis

PTMs

Glycosylation
Demethylation

Phosphorylation
Reduction

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC39A8

References

PMID: 12504855 by Begum N.A., et al. Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.

PMID: 26637978 by Boycott K.M., et al. Autosomal-recessive intellectual disability with cerebellar atrophy syndrome caused by mutation of the manganese and zinc transporter gene SLC39A8.