Protein unc-93 homolog B1 (Unc93b1)

Plays an essential role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (such as TLR3, TLR7 and TLR9) from the endoplasmic reticulum into endolysosomes where they can engage pathogen nucleotides and activate signaling cascades.

May play a role in autoreactive B- cells removal. .