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- Table of Contents
Facts about Cleavage and polyadenylation specificity factor subunit 3.
Also involved with the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein which induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs.
Human | |
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Gene Name: | CPSF3 |
Uniprot: | Q9UKF6 |
Entrez: | 51692 |
Belongs to: |
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metallo-beta-lactamase superfamily |
cleavage and polyadenylation specific factor 3, 73kD subunit; cleavage and polyadenylation specific factor 3, 73kDa; cleavage and polyadenylation specificity factor 3; Cleavage and polyadenylation specificity factor 73 kDa subunit; cleavage and polyadenylation specificity factor subunit 3; CPSF 73 kDa subunit; CPSF-73; CPSF73CPSF; EC 3.1.27; EC 3.1.27.-; mRNA 3'-end-processing endonuclease CPSF-73; YSH1
Mass (kDA):
77.486 kDA
Human | |
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Location: | 2p25.1 |
Sequence: | 2; NC_000002.12 (9423537..9473110) |
Nucleus.
PMID: 14749727 by Kaufmann I., et al. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.
PMID: 15037765 by Ryan K., et al. Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.