TRMU Antibodies

AND TRMU ELISA kits, TRMU Proteins

Many biological assays use antibodies to detect TRMU, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRMU in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRMU antibodies...

We validate the specificity of these antibodies to TRMU by testing them on tissues known to express TRMU positively and negatively. Browse below to find the TRMU antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRMU Infographic by Boster Bio

All TRMU Products

Product

Figures

Specificity

Applications

Price

TRMT1 (TRMU) (NM_018006) Human Recombinant Protein

$1249
Cat # PROTO75648
20 µg

Anti-TRMT1 (TRMU) Mouse Monoclonal Antibody [Clone ID: OTI2A4]

Dog, Human, Monkey, Mouse, Rat

IF, WB

$523
Cat # M06698
100 µl

TRMT1 (TRMU) (NM_018006) Human Over-expression Lysate

Human

$960
Cat # LS055687
100 µg

TRMU Overview

Facts about Mitochondrial tRNA-specific 2-thiouridylase 1.

TRMU 3D structure. Source: alphafold

Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU)

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position.

ATP is required to trigger the C2 atom of the wobble base. .

Gene Information

Human
Gene Name:	TRMU
Uniprot:	O75648
Entrez:	55687

Family

Belongs to:

MnmA/TRMU family

Alternative Names

EC 2.8.1; EC 2.8.1.-; FLJ10140; mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase; mitochondrial tRNA-specific 2-thiouridylase 1; MTO2 homolog; MTO2MGC99627; MTU1; TRMT; TRMT1; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase; TRNT1

Molecular Weight

Mass (kDA):
47.745 kDA

Genomic Context


Human

Location:	22q13.31
Sequence:	22; NC_000022.11 (46335714..46357340)

Tissue Specificity

Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.

Subcellular Localizations

Mitochondrion.

Diseases

Complete Hearing Loss
Mitochondrial Diseases
Mitochondrial Respiratory Chain Deficiencies
Liver Diseases
Myopathy
Acidosis
Liver Failure
Acidosis, Lactic
Merrf Syndrome
Mitochondrial Encephalomyopathies
Liver Failure, Acute
Epilepsy

Epilepsies, Myoclonic
Sensorineural Hearing Loss (disorder)
Malnutrition
Deafness Congenital
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Fetal Growth Retardation

Pathways

Translation
Trna Modification
Mitochondrial Translation
Pathogenesis
Rna Modification
Ribosome Biogenesis

Mitochondrial Trna Modification

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRMU

References

PMID: 16513084 by Yan Q., et al. Human TRMU encoding the mitochondrial 5-methylaminomethyl-2- methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations.

PMID: 15509579 by Umeda N., et al. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.