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Transmembrane protein 100 Antibodies
AND TMEM100 ELISA kits, Transmembrane protein 100 Proteins
Many biological assays use antibodies to detect Transmembrane protein 100, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 100 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 100 antibodies...
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TMEM100 Infographic by Boster Bio
All TMEM100 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
IHC, WB
$523
Cat # M09266
100 µl
Cat # M09266
100 µl
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M09266-1
100 µl
Cat # M09266-1
100 µl
TMEM100 Overview
Facts about Transmembrane protein 100.
Transmembrane protein 100 (TMEM100)
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons.
Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TMEM100 |
| Uniprot: | Q9NV29 |
| Entrez: | 55273 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Transmembrane protein 100
Molecular Weight
Mass (kDA):
14.386 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q22 |
| Sequence: | 17; NC_000017.11 (55719627..55732081, complement) |
Tissue Specificity
Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
Interacting Proteins
- CCDC57
- MEOX2
- TMEM79
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM100
bosterbio.com/bosterbio-gene-info-cards/TMEM100
References
PMID: 22783020 by Somekawa S., et al. Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.
PMID: 23485812 by Eisenman S.T., et al. Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves.