Tet3 Antibodies

AND Tet3 ELISA kits, Tet3 Proteins

Many biological assays use antibodies to detect Tet3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tet3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tet3 antibodies...

We validate the specificity of these antibodies to Tet3 by testing them on tissues known to express Tet3 positively and negatively. Browse below to find the Tet3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tet3 Infographic by Boster Bio

All Tet3 Products

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Anti-TET3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A03371
0.1 mg

Anti-TET3 Mouse Monoclonal Antibody [Clone ID: OTI11E11]

Human, Mouse, Rat

IHC, WB

$523
Cat # M03371
100 µl

Tet3 Overview

Facts about Methylcytosine dioxygenase TET3.

Methylcytosine dioxygenase TET3 (Tet3)

Dioxygenase that catalyzes the conversion of the modified genomic foundation 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming from the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC into 5-carboxylcytosine (5caC).

Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and leads to modulate the expression of numerous developmental genes.

Gene Information

Mouse
Gene Name:	Tet3
Uniprot:	Q8BG87
Entrez:	194388

Family

Belongs to:

TET family

Alternative Names

EC 1.14.11.n2; hCG_40738; KIAA0401; methylcytosine dioxygenase TET3; MGC22014; probable methylcytosine dioxygenase TET3; tet oncogene family member 3

Molecular Weight

Mass (kDA):
194.792 kDA

Genomic Context


Mouse

Location:	6\|6 C3
Sequence:	6;

Tissue Specificity

Highly expressed in oocytes and zygotes. Not expressed in embryonic stem cells (ES cells).

Diseases

Malignant Neoplasms
Cell Transformation, Neoplastic
Myelomonocytic Leukemia
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Neoplasms
Leukemia
Leukemia, Myelomonocytic, Chronic
Reperfusion Injury
Ischemia
Colonic Neoplasms
Schizophrenia

Malignant Tumor Of Colon
Myeloproliferative Disease
Psychotic Disorders
Autistic Disorder
Neuropathology Disease
Bipolar Disorder
Dysmyelopoietic Syndromes

Pathways

Demethylation
Methylation
Dna Demethylation
Dna Methylation
Fertilization
Cell Activation
Cell Cycle Checkpoint
Aging
Mitosis
T Cell Activation
Localization
Embryo Development
Response To Oxidative Stress

Maintenance Of Dna Methylation
Cell Division
Cell Cycle
Dna Modification
Blastocyst Development
Cell Differentiation
Oncogenesis

PTMs

Demethylation
Oxidation

Methylation
Deamination

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tet3

References

PMID: 23217707 by Xu Y., et al. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.

PMID: 23690950 by Liu N., et al. Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules.