TRPV3 Antibodies

Transient receptor potential cation channel subfamily V member 3 (TRPV3)

Putative receptor-activated non-selective calcium permeant cation channel. It's activated by benign (heat ) temperatures and reveals an increased reaction at noxious temperatures greater than 39 degrees Celsius.

Activation exhibits an outward rectification. May associate with TRPV1 and might modulate its activity.

Gene Information

Human
Gene Name:	TRPV3
Uniprot:	Q8NET8
Entrez:	162514

Family

Belongs to:
transient receptor (TC 1.A.4) family

Alternative Names

transient receptor potential cation channel subfamily V member 3; transient receptor potential cation channel, subfamily V, member 3; TRPV3; vanilloid receptor 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; Vanilloid R-like 3; VRL3; VRL-3

Molecular Weight

Mass (kDA):
90.636 kDA

Genomic Context

Human
Location:	17p13.2
Sequence:	17; NC_000017.11 (3510502..3557812, complement)

Tissue Specificity

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

• Pain
• Inflammation
• Malignant Neoplasms
• Hyperalgesia
• Dermatitis
• Dermatologic Disorders
• Neuralgia
• Pruritus
• Chronic Pain
• Hypoxia
• Neoplasms
• Pathologic Vasoconstriction

• Neurogenic Inflammation
• Malignant Neoplasm Of Prostate
• Thermal Hyperalgesia
• Corneal Diseases
• Acute Onset Pain
• Stenosis

Pathways

• Sensitization
• Hypersensitivity
• Localization
• Membrane Depolarization
• Vasodilation
• Cell Death
• Pathogenesis
• Secretion
• Transport
• Immune Response
• Reflex
• Inflammatory Response
• Vasoconstriction

• Wound Healing
• Cell Proliferation
• Membrane Hyperpolarization
• Keratinocyte Proliferation
• Keratinization
• Osteoclast Differentiation
• Catagen

PTMs

• Nitrosylation

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPV3

Boster Bio - Best Uses Of The TRPV3 Marker

You have found the right place if looking for an antibody to TRPV3. Unlike other companies, Boster Bio has a long list of positive and negative test samples to ensure its high specificity and affinity. They also offer product credit to the first reviewers, and generous rewards to scientists from all over. Boster Bio stands out in this regard.

Boster Bio

Booster bios are a popular way to increase testosterone levels. But they aren't all that you can use to boost testosterone levels. Researchers discovered that the gene can also help in other ways. We'll look at some products in this article. These products are also beneficial in treating certain health conditions, including anxiety and depression. Let's discuss the best uses of TRPV3 before we start.

Rooh Afza

Rooh Afza (or Rooh Afza) is a popular herbal tea. It contains a mixture plant extracts that possess medicinal properties, such khurfa or kasni. Rooh Afza is refreshing and rejuvenating because of its anti-viral, immune modulating, and rejuvenating compounds. Further research is needed to determine its therapeutic value. Coronavirus infections can be cured by traditional medicinal plants. They may be used either as a single agent or in combination.

Anti-GAPDH

There are many ways to use the TRPV3 mark. A recent study showed that dyclonine reduces endogenous TRPV3 channels within mouse keratinocytes. However, it's not known if anti–GAPDH antibodies also suppress TRPV3 signal. This article will discuss a possible solution to this problem.

The study showed that TRPV3 was expressed differently in prostate cancer and normal prostates. Further investigation revealed that these three proteins are involved in calcium homeostasis. TRPV3 also promoted the proliferation of A549- and h2299-type lung cancer cells. Future studies will investigate how TRPV3 influences the proliferation of lung cancer cells. This study identifies several ways in which anti-GAPDH antibodies can be used in clinical trials.

TRPV3 has a significant effect on cell cycle kinetics in A549 and h2299 cells. The cell cycle phase was determined after the incorporation propidium iodide. The samples were analyzed 24 hrs after plating. Western blot analysis was used to identify changes in cell cycle-related factors. Data are represented as the mean + SDS of triplicates. This marker is used in many clinical settings.

The TRPV3 gene marker has been successfully used for human cancer research and other purposes. There are currently many anti-GAPDH medications on the market. There is still much to be done to determine if anti-GAPDH drugs target TRPV3 mutants. Because GAPDH genes are highly variable and can differ between individuals, researchers could use the TRPV3 marker in order to determine the right treatment for each patient.

ICC

TRPV3's structure is known in both the closed and open state. During gating, TRPV3's interface between the bsheet and ARD fingers 3 slides relative each other. TRPV3 is modified by mutations of the tyrosine atoms to reduce the temperature dependence. Mutations in a single residue of cysteine can decrease current density but not affect the TRPV3 structures.

TRPV3's structure is known with a resolution of 4.3 A. Induced fitting docking was used to dock the protein to a ligand by the researchers. To facilitate docking, both the residue side chains (ligand) and side chains (residues) were made flexible. These experiments were successful in revealing the binding mode of the TRPV3 inhibitor. The low free energie of this mode makes it rational for TRPV3 to be bound.

The TRPV3 N-terminal finger 3 is positioned near the linker region of the transmembrane domain of an adjacent subunit. MPD stands short for membrane proximaldomain. In addition, MPD is connected to finger 3 in the ARD. The TRPV3 N terminal finger is also located near the C-terminal loop domain in the adjacent subunit.

Double cysteine mutant channel evoke whole cell currents even when mixed agonists are not present. These channels also produce large basal currents of -70mV. The conductance of single channels at -60 mV and +60mV was decreased by dyclonine. These results suggest that TRPV3 may have multiple roles in the nervous system. Its role for neurotransmission is unknown.

Immunofluorescence

TRPV3 can be used for immune modulation and prevention. It has been shown to have a high level of phagocytic activity and anti-viral activity. It is an ideal candidate for vaccine adjuvants (a type of immunostimulant). Researchers are interested in the TRPV3 marker being used for a variety of applications, including the development anti-hepatitis B vaccinations.

The TRPV3 marker is available as a monoclonal antibody with a dissociation constant of 10 to 12 moles/liter. It is also available with an immunoglobulin-sequence. This sequence has been used in both therapeutic and research applications. They can detect antigens in many types of tissues. TRPV3 can be used to aid in cancer immunotherapy.

TRPV3 is a marker that can be used to immunize whole cells with the antigen. Further, Nanobodies are screened for binding to antigens. Many publications describe the production of Nanobodies to be used in cell-associated antigens. A camelid cell line is immunized using this method. This immunization procedure results in a collection of Nanobodies. These Nanobodies bind to your target antigen.

Transmembrane drugs are important targets for drug development. These proteins are however difficult to isolate in their native form. Cell associated antigens have a conformation-dependent epitope, which is dependent on the location and anchoring of the antigen in the membrane. These molecules are often targeted with immunoglobulins. TRPV3 represents a promising tool to aid in drug discovery.