Tenascin-N Antibodies

AND TNN ELISA kits, Tenascin-N Proteins

Many biological assays use antibodies to detect Tenascin-N, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tenascin-N in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tenascin-N antibodies...

We validate the specificity of these antibodies to Tenascin-N by testing them on tissues known to express TNN positively and negatively. Browse below to find the TNN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNN Infographic by Boster Bio

All TNN Products

Product

Figures

Specificity

Applications

Price

Anti-Tenascin TNN Antibody (Monoclonal, BC-24)

6 Q&As

Human

IHC, ICC, WB

$370
Cat # MA1094
100 μg/vial

Anti-TENN TNN Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05722
100ul

TNN Overview

Facts about Tenascin-N.

TNN 3D structure. Source: alphafold

Tenascin-N (TNN)

Extracellular matrix protein which seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).

During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Gene Information

Human
Gene Name:	TNN
Uniprot:	Q9UQP3
Entrez:	63923

Family

Belongs to:

tenascin family

Alternative Names

tenascin N

Molecular Weight

Mass (kDA):
144.034 kDA

Genomic Context


Human

Location:	1q25.1
Sequence:	1; NC_000001.11 (175067833..175148075)

Tissue Specificity

Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Malignant Neoplasms
Neoplasm Metastasis
Melanoma
Malignant Neoplasm Of Breast
Neoplasms
Mammary Neoplasms
Muscle Spasticity
Skin Neoplasms
Tissue Adhesions
Melanocytic Nevus
Hemiplegia
Lung Injury

Stomach Neoplasms
Spinal Cord Injuries
Manganese Poisoning
Bone Neoplasms
Invasive Skin Melanoma
Carcinoma
Dysplasia

Pathways

Menstruation
Cell Migration
Osteoblast Differentiation
Cell Motility
Wound Healing
Localization

Excretion

PTMs

Nitration

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNN

References

PMID: 17909022 by Degen M., et al. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior.

PMID: 19884327 by Martina E., et al. Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro.