Transmembrane protein 199 Antibodies

AND TMEM199 ELISA kits, Transmembrane protein 199 Proteins

Many biological assays use antibodies to detect Transmembrane protein 199, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 199 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 199 antibodies...

We validate the specificity of these antibodies to Transmembrane protein 199 by testing them on tissues known to express TMEM199 positively and negatively. Browse below to find the TMEM199 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: KCTD11

TMEM199 Infographic by Boster Bio

All TMEM199 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Transmembrane protein 199 TMEM199 Antibody Picoband®

5 Q&As

Human, Mouse, Rat

ELISA, WB

$370
Cat # A14686-1
100 μg/vial

TMEM199 (NM_152464) Human Over-expression Lysate

Human

$628
Cat # LS147007
100 µg

TMEM199 Overview

Facts about Transmembrane protein 199.

TMEM199 3D structure. Source: alphafold

Transmembrane protein 199 (TMEM199)

Accessory component of this proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the action of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.

Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330).

Gene Information

Human
Gene Name:	TMEM199
Uniprot:	Q8N511
Entrez:	147007

Family

Belongs to:

No superfamily

Alternative Names

C17orf32; chromosome 17 open reading frame 32; MGC45714; transmembrane protein 199

Molecular Weight

Mass (kDA):
23.13 kDA

Genomic Context


Human

Location:	17q11.2
Sequence:	17; NC_000017.11 (28357647..28363683)

Subcellular Localizations

Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Partial colocalization with GOLGB1.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms

Interacting Proteins

CCDC155
ERLIN1

Pathways

Dna Amplification

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM199

References

PMID: 26833330 by Jansen J.C., et al. TMEM199 deficiency is a disorder of Golgi homeostasis characterized by elevated aminotransferases, alkaline phosphatase, and cholesterol and abnormal glycosylation.

PMID: 28296633 by Miles A.L., et al. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.