BTB/POZ domain-containing protein KCTD11 (KCTD11)

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated with an assortment of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the saying of cyclin-dependent kinase inhibitor CDKN1B.

Acts as likely substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by changing the atomic transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, maintaining GLI1 acetylated and inactive.