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- Table of Contents
Facts about Taste receptor type 2 member 43.
Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter substances increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.
Human | |
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Gene Name: | TAS2R43 |
Uniprot: | P59537 |
Entrez: | 259289 |
Belongs to: |
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G-protein coupled receptor T2R family |
Taste receptor type 2 member 43
Mass (kDA):
35.599 kDA
Human | |
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Location: | 12p13.2 |
Sequence: | 12; NC_000012.12 (11091287..11092313, complement) |
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. In airway epithelial cells, localizes to motile cilia.
PMID: 12379855 by Bufe B., et al. The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides.
PMID: 12584440 by Conte C., et al. Identification and characterization of human taste receptor genes belonging to the TAS2R family.