SSH2 Antibodies

AND SSH2 ELISA kits, SSH2 Proteins

Many biological assays use antibodies to detect SSH2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SSH2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SSH2 antibodies...

We validate the specificity of these antibodies to SSH2 by testing them on tissues known to express SSH2 positively and negatively. Browse below to find the SSH2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SSH2 Infographic by Boster Bio

All SSH2 Products

Product

Figures

Specificity

Applications

Price

Anti-SSH2 Antibody

Human, Mouse, Rat

$405
Cat # A08561
100ul

SSH2 Overview

Facts about Protein phosphatase Slingshot homolog 2.

SSH2 3D structure. Source: alphafold

Protein phosphatase Slingshot homolog 2 (SSH2)

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.

Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. .

Gene Information

Human
Gene Name:	SSH2
Uniprot:	Q76I76
Entrez:	85464

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.16; EC 3.1.3.48; hSSH-2L; KIAA1725protein phosphatase Slingshot homolog 2; MGC78588; slingshot 2; slingshot homolog 2 (Drosophila); SSH-2; SSH2L; SSH-2L; SSH-like protein 2

Molecular Weight

Mass (kDA):
158.216 kDA

Genomic Context


Human

Location:	17q11.2
Sequence:	17; NC_000017.11 (29625938..29930239, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton.

Diseases

Neoplasms
Cell Invasion
Stomach Neoplasms
Neoplasm Metastasis
Mutation, Out-of-frame
Neointima
Liver Carcinoma
High-frequency Microsatellite Instability
Tissue Adhesions
Microsatellite Instability
Neoplasm Invasiveness
Carcinoma
Vascular System Injuries

Malignant Neoplasm Of Stomach
Malignant Neoplasms
Posttransfusion Purpura
Colorectal Neoplasms
Formation, Neointima
Colorectal Cancer
Low-frequency Microsatellite Instability

Pathways

Cell Migration
Protein Phosphorylation
Actin Cytoskeleton Organization
Cytoskeleton Organization
Keratinocyte Migration
Muscle Cell Migration
Smooth Muscle Cell Migration
Wound Healing

Virulence
Rna Interference

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSH2

References

PMID: 11832213 by Niwa R., et al. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

PMID: 14531860 by Ohta Y., et al. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.