POLG Antibodies

AND POLG ELISA kits, POLG Proteins

Many biological assays use antibodies to detect POLG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLG antibodies...

We validate the specificity of these antibodies to POLG by testing them on tissues known to express POLG positively and negatively. Browse below to find the POLG antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLG Infographic by Boster Bio

All POLG Products

Product

Figures

Specificity

Applications

Price

Anti-DPOG1 POLG Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02796
100ul

Anti-DNA Polymerase gamma Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M02796
100 μl/vial

POLG Overview

Facts about DNA polymerase subunit gamma-1.

POLG 3D structure. Source: alphafold

DNA polymerase subunit gamma-1 (POLG)

Involved in the replication of mitochondrial DNA.
Associates with mitochondrial DNA.

Gene Information

Human
Gene Name:	POLG
Uniprot:	P54098
Entrez:	5428

Family

Belongs to:

DNA polymerase type-A family

Alternative Names

DNA polymerase subunit gamma-1; EC 2.7.7.7; FLJ27114; MDP1; MIRAS; Mitochondrial DNA polymerase catalytic subunit; MTDPS4A; PolG, catalytic subunit; POLG1MTDPS4B; PolG-alpha; POLGAPEO; polymerase (DNA directed), gamma; SANDO; SCAE

Molecular Weight

Mass (kDA):
139.562 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (89316320..89334824, complement)

Subcellular Localizations

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Diseases

Mitochondrial Diseases
Ophthalmoplegia
Chronic Progressive External Ophthalmoplegia
External Ophthalmoplegia
Alpers Syndrome (disorder)
Ataxia
Epilepsy
Diffuse Cerebral Sclerosis Of Schilder
Myopathy
Mitochondrial Dna Depletion
Secondary Parkinson Disease
Liver Failure

Parkinson Disease
Dysarthria
Liver Diseases
Encephalopathies
Mitochondrial Myopathies
Infertility

Interacting Proteins

POLG2

Pathways

Oxidative Phosphorylation
Pathogenesis
Aging
Dna Replication
Mitochondrial Dna Replication
Transport
Embryo Development
Electron Transport
Fertilization
Translation
Menopause
Cell Death
Spermatogenesis

Dna Repair
Electron Transport Chain
Senescence
Cell Migration
Mitochondrial Translation
Mismatch Repair
Sperm Motility

PTMs

Phosphorylation
Oxidation

Nitration
Methylation

Research Areas

DNA Polymerases
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLG

References

PMID: 8884268 by Ropp P.A., et al. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma.

PMID: 9034326 by Lecrenier N.L., et al. Mitochondrial DNA polymerases from yeast to man: a new family of polymerases.