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- Table of Contents
Facts about Sorting nexin-6.
The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is included in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex works to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).
Human | |
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Gene Name: | SNX6 |
Uniprot: | Q9UNH7 |
Entrez: | 58533 |
Belongs to: |
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sorting nexin family |
MGC3157; MSTP010; sorting nexin 6; sorting nexin-6; TFAF2; TRAF4-associated factor 2; tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Mass (kDA):
46.649 kDA
Human | |
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Location: | 14q13.1 |
Sequence: | 14; NC_000014.9 (34561093..34630148, complement) |
Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus. Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus.
PMID: 11485546 by Teasdale R.D., et al. A large family of endosome-localized proteins related to sorting nexin 1.
PMID: 11591366 by Ishibashi Y., et al. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.