Protein cereblon Antibodies

AND CRBN ELISA kits, Protein cereblon Proteins

Many biological assays use antibodies to detect Protein cereblon, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein cereblon in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein cereblon antibodies...

We validate the specificity of these antibodies to Protein cereblon by testing them on tissues known to express CRBN positively and negatively. Browse below to find the CRBN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRBN Infographic by Boster Bio

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Anti-Protein cereblon CRBN Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A00983
0.1 mg

CRBN (NM_016302) Human Over-expression Lysate

Human

$628
Cat # LS051185
100 µg

CRBN Overview

Facts about Protein cereblon.

CRBN 3D structure. Source: alphafold

Protein cereblon (CRBN)

Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Regular degradation of key regulatory proteins is necessary for normal limb outgrowth and expression of the fibroblast growth factor FGF8.

May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.