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- Table of Contents
Facts about Testis anion transporter 1.
May be involved with a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical part of the sperm annulus that is vital for correct sperm tail differentiation and motility and hence male fertility.
Human | |
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Gene Name: | SLC26A8 |
Uniprot: | Q96RN1 |
Entrez: | 116369 |
Belongs to: |
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SLC26A/SulP transporter (TC 2.A.53) family |
solute carrier family 26, member 8
Mass (kDA):
109.006 kDA
Human | |
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Location: | 6p21.31 |
Sequence: | 6; NC_000006.12 (35943514..36024641, complement) |
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.
Membrane; Multi-pass membrane protein. Located at the annulus ring structure within the sperm cell.
PMID: 11278976 by Toure A., et al. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.
PMID: 11834742 by Lohi H., et al. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.