This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Interleukin-22 receptor subunit alpha-2.
May play an important role as an IL22 antagonist in the regulation of inflammatory reactions. .
Human | |
---|---|
Gene Name: | IL22RA2 |
Uniprot: | Q969J5 |
Entrez: | 116379 |
Belongs to: |
---|
type II cytokine receptor family |
class II cytokine receptor; CRF2-10; CRF2-S1IL22BP; CRF2-X; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2, soluble 1; IL-22 RA2; IL-22 receptor subunit alpha-2; IL22BP; IL-22BP; IL-22BPCRF2X; IL22RA2; IL-22RA2; IL-22R-alpha-2; interleukin 22 receptor, alpha 2; interleukin 22-binding protein; interleukin-22 receptor subunit alpha-2; Interleukin-22-binding protein; MGC150509; MGC150510; zcytoR16
Mass (kDA):
30.55 kDA
Human | |
---|---|
Location: | 6q23.3 |
Sequence: | 6; NC_000006.12 (137143820..137173644, complement) |
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
Secreted.
PMID: 11607789 by Gruenberg B.H., et al. A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta.
PMID: 11390454 by Kotenko S.V., et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity.