SIGLEC10 Antibodies

AND SIGLEC10 ELISA kits, SIGLEC10 Proteins

Many biological assays use antibodies to detect SIGLEC10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGLEC10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGLEC10 antibodies...

We validate the specificity of these antibodies to SIGLEC10 by testing them on tissues known to express SIGLEC10 positively and negatively. Browse below to find the SIGLEC10 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIGLEC10 Infographic by Boster Bio

All SIGLEC10 Products

Product

Figures

Specificity

Applications

Price

Anti-SIG10 SIGLEC10 Antibody

Human

ELISA, WB

$380
Cat # A07893
100ul

Human Siglec-10 Recombinant Protein

SDS-PAGE

$287
Cat # PROTQ96LC7
Starting from 10ug

SIGLEC10 (NM_033130) Human Over-expression Lysate

Human

$628
Cat # LS089790
100 µg

SIGLEC10 Overview

Facts about Sialic acid-binding Ig-like lectin 10.

SIGLEC10 3D structure. Source: alphafold

Sialic acid-binding Ig-like lectin 10 (SIGLEC10)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

In the immune response, seems to function as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling.

Gene Information

Human
Gene Name:	SIGLEC10
Uniprot:	Q96LC7
Entrez:	89790

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

MGC126774; PRO940; sialic acid binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; Siglec10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SLG2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7

Molecular Weight

Mass (kDA):
76.592 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51410020..51417642, complement)

Tissue Specificity

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Secreted.

Diseases

Inflammation
Systemic Infection
Intestinal Perforation
Hiv Infections
Asthma
Communicable Diseases
Tissue Adhesions
Pre-eclampsia

Immunologic Tolerance
Sequelae Aspects

Pathways

Cell Activation
Cytokine Production
Cell-cell Recognition
Cell Death
Cell Cycle
Immune Response

Virulence

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC10

References

PMID: 11409878 by Yousef G.M., et al. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants.

PMID: 11284738 by Munday J., et al. Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor.