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- Table of Contents
Facts about Shieldin complex subunit 2.
Mediates various NHEJ- dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). .
Human | |
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Gene Name: | SHLD2 |
Uniprot: | Q86V20 |
Entrez: | 54537 |
Belongs to: |
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SHLD2 family |
Shieldin complex subunit 2
Mass (kDA):
93.705 kDA
Human | |
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Location: | 10q23.2 |
Sequence: | 10; NC_000010.11 (87094478..87191468) |
Nucleus. Chromosome. Localizes to nuclear foci in response to DNA damage.
PMID: 29656893 by Gupta R., et al. DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity.
PMID: 29789392 by Tomida J., et al. FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.