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, No Gclids
Protein RCC2 Antibodies
AND RCC2 ELISA kits, Protein RCC2 Proteins
Many biological assays use antibodies to detect Protein RCC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein RCC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein RCC2 antibodies...
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RCC2 Overview
Facts about Protein RCC2.
Protein RCC2 (RCC2)
Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:23388455, PubMed:12919680, PubMed:26158537).
Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455).
Gene Information
| Human | |
|---|---|
| Gene Name: | RCC2 |
| Uniprot: | Q9P258 |
| Entrez: | 55920 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp762N0610; KIAA1470; protein RCC2; RCC1-like protein TD-60; regulator of chromosome condensation 2; TD60; TD-60; Telophase disk protein of 60 kDa
Molecular Weight
Mass (kDA):
56.085 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.13 |
| Sequence: | 1; NC_000001.11 (17406760..17439677, complement) |
Subcellular Localizations
Nucleus, nucleolus. Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455).
Diseases
- Neoplasms
- Renal Cell Carcinoma
- Tissue Adhesions
- Carcinoma
- Basal Cell Carcinoma
- Peritoneal Neoplasms
- Right Ventricular Hypertrophy
- Melanoma
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Kidney Neoplasm
- Abdominal Neoplasms
Pathways
- Mitosis
- Cell Adhesion
- Cytokinesis
- Cell Migration
- Shoot Formation
- Pigmentation
- Metaphase
- Endocytosis
- Localization
- Chromosome Segregation
- Disease Resistance
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RCC2
bosterbio.com/bosterbio-gene-info-cards/RCC2
References
PMID: 12919680 by Mollinari C., et al. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.
PMID: 1939370 by Andreassen P.R., et al. Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.