NKRF Antibodies

AND NKRF ELISA kits, NKRF Proteins

Many biological assays use antibodies to detect NKRF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NKRF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NKRF antibodies...

We validate the specificity of these antibodies to NKRF by testing them on tissues known to express NKRF positively and negatively. Browse below to find the NKRF antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NKRF Infographic by Boster Bio

All NKRF Products

Product

Figures

Specificity

Applications

Price

Anti-NF-kappa-B-repressing factor NKRF Antibody

Human, Mouse, Rat

$405
Cat # A06610
100ul

NKRF (NM_017544) Human Recombinant Protein

$1249
Cat # PROTO15226
20 µg

Anti-NKRF Mouse Monoclonal Antibody [Clone ID: OTI4C2]

Human, Mouse

$523
Cat # M06610
100 µl

NKRF (NM_017544) Human Over-expression Lysate

Human

$628
Cat # LS055922
100 µg

NKRF Overview

Facts about NF-kappa-B-repressing factor.

NKRF 3D structure. Source: alphafold

NF-kappa-B-repressing factor (NKRF)

Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of specific NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity.

Also included in the regulation of IL-8 transcription. .

Gene Information

Human
Gene Name:	NKRF
Uniprot:	O15226
Entrez:	55922

Family

Belongs to:

No superfamily

Alternative Names

ITBA4NFkB-repressing factor; NF-kappaB repressing factor; NFKB repressing factor; NRFNF-kappa-B-repressing factor; Protein ITBA4; Transcription factor NRF

Molecular Weight

Mass (kDA):
77.673 kDA

Genomic Context


Human

Location:	Xq24
Sequence:	X; NC_000023.11 (119588337..119606424, complement)

Tissue Specificity

Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.

Subcellular Localizations

Nucleus, nucleolus.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Virus Diseases
Inflammation
Metaplasia
Helicobacter Infections
Classical Swine Fever
Lichen Planus, Oral
Orbital Separation Excessive
Inflammatory Response
Ulcer

Immunologic Deficiency Syndromes
Helicobacter Pylori Infection
Ventricular Septal Defects
Skin Abnormalities
Nervousness
Pancreatic Neoplasm

Interacting Proteins

DHX15
DHX58
PRKRA

Pathways

Translation
Gene Silencing
Mrna Stabilization
Cellular Process
Dna Repair
Immune Response
Regulation Of Gene Expression
Virulence
Localization
Macrophage Activation
Inflammatory Response
Host-pathogen Interaction
Cytokine Production

Phagocytosis
Cell Death
Cell Differentiation
Cell Growth
Rna Interference
Contact Inhibition
Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKRF

References

PMID: 10562553 by Nourbakhsh M., et al. Constitutive silencing of IFN-beta promoter is mediated by NRF (NF- kB-repressing factor), a nuclear inhibitor of NF-kB.

PMID: 9224902 by Frattini A., et al. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.