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- Table of Contents
Facts about Protein arginine N-methyltransferase 7.
Especially mediates the symmetric dimethylation of histone H4'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL in the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these websites.
Human | |
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Gene Name: | PRMT7 |
Uniprot: | Q9NVM4 |
Entrez: | 54496 |
Belongs to: |
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class I-like SAM-binding methyltransferase superfamily |
[Myelin basic protein]-arginine N-methyltransferase PRMT7; EC 2.1.1; EC 2.1.1.125; EC 2.1.1.126; FLJ10640; Histone-arginine N-methyltransferase PRMT7; KIAA1933EC 2.1.1.-; myelin basic protein-arginine N-methyltransferase; protein arginine methyltransferase 7; protein arginine N-methyltransferase 7
Mass (kDA):
78.459 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (68310982..68360876) |
Cytoplasm, cytosol. Nucleus.
PMID: 15044439 by Miranda T.B., et al. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.
PMID: 15494416 by Lee J.-H., et al. PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine.