TMCO1 Antibodies

AND TMCO1 ELISA kits, TMCO1 Proteins

Many biological assays use antibodies to detect TMCO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TMCO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TMCO1 antibodies...

We validate the specificity of these antibodies to TMCO1 by testing them on tissues known to express TMCO1 positively and negatively. Browse below to find the TMCO1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMCO1 Infographic by Boster Bio

All TMCO1 Products

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TMCO1 (NM_019026) Human Recombinant Protein

$813
Cat # PROTQ9UM00
20 µg

TMCO1 (NM_019026) Human Over-expression Lysate

Human

$628
Cat # LS054499
100 µg

TMCO1 Overview

Facts about Calcium load-activated calcium channel.

TMCO1 3D structure. Source: alphafold

Calcium load-activated calcium channel (TMCO1)

Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum shop (PubMed:27212239).

Gene Information

Human
Gene Name:	TMCO1
Uniprot:	Q9UM00
Entrez:	54499

Family

Belongs to:

TMCO1 family

Alternative Names

HP10122; PCIA3; PNAS-136; putative membrane protein; RP11-466F5.7; TMCC4; transmembrane and coiled-coil domain-containing protein 1; transmembrane and coiled-coil domains 1; transmembrane and coiled-coil domains 4; Transmembrane and coiled-coil domains protein 4; Xenogeneic cross-immune protein PCIA3

Molecular Weight

Mass (kDA):
27.079 kDA

Genomic Context


Human

Location:	1q24.1
Sequence:	1; NC_000001.11 (165724291..165768922, complement)

Tissue Specificity

Widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). Present in most tissues in the eye, including the trabecular meshwork and retina (at protein level) (PubMed:22714896).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. The first transmembrane region is required for localization to the endoplasmic reticulum (PubMed:27212239). A publication reported localization in cytoplasm and nucleus (PubMed:22714896). Nuclear localization is however in contradiction with two other reports (PubMed:10393320, PubMed:27212239).

Diseases

Glaucoma, Open-angle
Glaucoma
Intraocular Pressure Disorder
Blind Vision
Primary Open Angle Glaucoma
Brachycephaly
Gingival Hyperplasia
Congenital Funnel Chest
Hereditary Diseases
Congenital Musculoskeletal Anomalies
Craniofacial Abnormalities
Low Set Ears

Microdontia
Congenital Deformity Of Scapula
Congenital Flat Foot
Fusion Of Spine (disease)
Congenital Elevation Of Scapula
Tooth Abnormalities

Pathways

Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMCO1

References

PMID: 10393320 by Iwamuro S., et al. Multi-ubiquitination of a nascent membrane protein produced in a rabbit reticulocyte lysate.

PMID: 20018682 by Xin B., et al. Homozygous frameshift mutation in TMCO1 causes a syndrome with craniofacial dysmorphism, skeletal anomalies, and mental retardation.