PRDM14 Antibodies

AND PRDM14 ELISA kits, PRDM14 Proteins

Many biological assays use antibodies to detect PRDM14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRDM14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRDM14 antibodies...

We validate the specificity of these antibodies to PRDM14 by testing them on tissues known to express PRDM14 positively and negatively. Browse below to find the PRDM14 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRDM14 Infographic by Boster Bio

All PRDM14 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PRDM14 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03870-1
100ul

Anti-PRDM14 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03870-2
100 μg/vial

PRDM14 (NM_024504) Human Over-expression Lysate

Human

$628
Cat # LS063978
100 µg

PRDM14 Overview

Facts about PR domain zinc finger protein 14.

PRDM14 3D structure. Source: alphafold

PR domain zinc finger protein 14 (PRDM14)

Transcription factor which has both negative and positive roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells.

May play a vital role in germ cell development at two levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and effective epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is needed for the functions in pluripotency and germ cell formation (By similarity).

Gene Information

Human
Gene Name:	PRDM14
Uniprot:	Q9GZV8
Entrez:	63978

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

MGC59730; PFM11; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing protein 14; PRDM14; PR-domain zinc finger protein 14

Molecular Weight

Mass (kDA):
64.062 kDA

Genomic Context


Human

Location:	8q13.3
Sequence:	8; NC_000008.11 (70051613..70071252, complement)

Tissue Specificity

Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Neoplasms
Mammary Neoplasms
Invasive Breast Carcinoma
Carcinoma
Carcinoma In Situ
Noninfiltrating Intraductal Carcinoma
Cell Transformation, Neoplastic
Cardiomyopathy, Familial Idiopathic
Acute Lymphocytic Leukemia
Leukemia

Ductal Carcinoma
Teratoma
Myc Gene Amplification
Infertility
Malignant Neoplasm Of Lung
Carcinogenesis
Lymphoma

Interacting Proteins

ATPAF2
BEX2
CBFA2T2
CDCA7L
EIF4E2

GPATCH2L
HEXIM2
Hoxa1
HSPB7
PRKAB2

PSMA1
RAD51D
RBM10
RCOR3
TEKT4

TTC32

Pathways

Cell Development
Germ Cell Development
Gastrulation
Methylation
Cell Growth
Gene Silencing
Dna Demethylation
Spermatogenesis
Demethylation
Senescence

Cell Differentiation
Histone Methylation
Heart Development
Rna Interference
Oncogenesis

PTMs

Methylation

Demethylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRDM14

References

PMID: 17942894 by Nishikawa N., et al. Gene amplification and overexpression of PRDM14 in breast cancers.

PMID: 20953172 by Chia N.Y., et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.