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- Table of Contents
Facts about Protein TMEPAI.
Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 which translocates into the nucleus to regulate transcription. Through discussion with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487).
Human | |
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Gene Name: | PMEPA1 |
Uniprot: | Q969W9 |
Entrez: | 56937 |
Belongs to: |
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PMEPA1 family |
prostate transmembrane protein, androgen induced 1; Solid tumor-associated 1 protein; STAG1prostate androgen induced RNA; transmembrane prostate androgen-induced protein
Mass (kDA):
31.609 kDA
Human | |
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Location: | 20q13.31 |
Sequence: | 20; NC_000020.11 (57648392..57711536, complement) |
Highest expression in prostate. Also expressed in ovary.
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
PMID: 10873380 by Xu L.L., et al. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate.
PMID: 11568975 by Rae F.K., et al. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors.