PLEKHA2 Antibodies

AND PLEKHA2 ELISA kits, PLEKHA2 Proteins

Many biological assays use antibodies to detect PLEKHA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHA2 antibodies...

We validate the specificity of these antibodies to PLEKHA2 by testing them on tissues known to express PLEKHA2 positively and negatively. Browse below to find the PLEKHA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHA2 Infographic by Boster Bio

All PLEKHA2 Products

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Specificity

Applications

Price

PLEKHA2 (NM_021623) Human Recombinant Protein

$1062
Cat # PROTQ9HB19
20 µg

PLEKHA2 (NM_021623) Human Over-expression Lysate

Human

$960
Cat # LS059339
100 µg

PLEKHA2 Overview

Facts about Pleckstrin homology domain-containing family A member 2.

PLEKHA2 3D structure. Source: alphafold

Pleckstrin homology domain-containing family A member 2 (PLEKHA2)

Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).

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Gene Information

Human
Gene Name:	PLEKHA2
Uniprot:	Q9HB19
Entrez:	59339

Family

Belongs to:

No superfamily

Alternative Names

FLJ25921; PH domain-containing family A member 2; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; pleckstrin homology domain-containing family A member 2; pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2; tandem PH Domain containing protein-2; tandem PH domain-containing protein 2; TAPP2; TAPP-2

Molecular Weight

Mass (kDA):
47.255 kDA

Genomic Context


Human

Location:	8p11.22
Sequence:	8; NC_000008.11 (38901346..38973912)

Tissue Specificity

Highly expressed in heart, kidney, spleen and peripheral blood leukocytes. Detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta and lung.

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.

Diseases

Leukemia
Lymphoma
Malignant Paraganglionic Neoplasm
B-cell Lymphomas
Tissue Adhesions
Insulin Sensitivity
Prolymphocytic Leukemia
T-cell Prolymphocytic Leukemia
Neoplasms

Leukemia, B-cell
Lymphoid Leukemia
Lymphoproliferative Disorders
Uniparental Disomy

Interacting Proteins

GIPC2
M1AP

Pathways

Cell Activation
B Cell Activation
Localization
Cell Adhesion
T Cell Activation
Lymphocyte Activation

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHA2

References

PMID: 11001876 by Dowler S.J., et al. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.