PLEKHA1 Antibodies

AND PLEKHA1 ELISA kits, PLEKHA1 Proteins

Many biological assays use antibodies to detect PLEKHA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHA1 antibodies...

We validate the specificity of these antibodies to PLEKHA1 by testing them on tissues known to express PLEKHA1 positively and negatively. Browse below to find the PLEKHA1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLEKHA1 Infographic by Boster Bio

All PLEKHA1 Products

Product

Figures

Specificity

Applications

Price

Anti-PKHA1 PLEKHA1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A08988
100ul

PLEKHA1 (NM_021622) Human Recombinant Protein

$1249
Cat # PROTQ9HB21
20 µg

Anti-TAPP1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M08988
100 μl/vial

Anti-PLEKHA1 Antibody Picoband™

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A08988-1
100 µg/vial

PLEKHA1 Overview

Facts about Pleckstrin homology domain-containing family A member 1.

PLEKHA1 3D structure. Source: alphafold

Pleckstrin homology domain-containing family A member 1 (PLEKHA1)

Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.

Gene Information

Human
Gene Name:	PLEKHA1
Uniprot:	Q9HB21
Entrez:	59338

Family

Belongs to:

No superfamily

Alternative Names

family A (phosphoinositide bindingspecific) member 1; PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide bindingspecific) member 1; PLEKHA1; TAPP1

Molecular Weight

Mass (kDA):
45.553 kDA

Genomic Context


Human

Location:	10q26.13
Sequence:	10; NC_000010.11 (122374675..122442600)

Tissue Specificity

Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.

Diseases

Age Related Macular Degeneration
Blind Vision
Abnormal Degeneration
Macule
Exudative Age-related Macular Degeneration
Maculopathy
Disorder Of Eye
Neoplasms
Visual Impairment
Dysequilibrium Syndrome
Degenerative Disorder
Dry Eye Syndromes

Hereditary Diseases
Overlying Behavior
B-cell Lymphomas
Pathological Dilatation
Tissue Adhesions
Diabetes Mellitus
Insulin Sensitivity

Interacting Proteins

MPDZ
SH3BP4

Pathways

Localization
Pathogenesis
Lymphocyte Activation
Cell Activation
Cell Migration
Protein Folding
T Cell Activation
Lipid Binding
Integrin Activation

Macropinocytosis
B Cell Activation
Secretion

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHA1

References

PMID: 11001876 by Dowler S.J., et al. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

PMID: 11802782 by Kimber W.A., et al. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain- containing protein MUPP1 in vivo.