PI4K2B Antibodies

AND PI4K2B ELISA kits, PI4K2B Proteins

Many biological assays use antibodies to detect PI4K2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PI4K2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PI4K2B antibodies...

We validate the specificity of these antibodies to PI4K2B by testing them on tissues known to express PI4K2B positively and negatively. Browse below to find the PI4K2B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PI4K2B Infographic by Boster Bio

All PI4K2B Products

Product

Figures

Specificity

Applications

Price

PI 4 Kinase type 2 beta (PI4K2B) (NM_018323) Human Recombinant Protein

$1249
Cat # PROTQ8TCG2
20 µg

PI 4 Kinase type 2 beta (PI4K2B) (NM_018323) Human Over-expression Lysate

Human

$628
Cat # LS055300
100 µg

Anti-PI4K2B Antibody Picoband™

Human, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A11023-1
100 µg/vial

PI4K2B Overview

Facts about Phosphatidylinositol 4-kinase type 2-beta.

PI4K2B 3D structure. Source: alphafold

Phosphatidylinositol 4-kinase type 2-beta (PI4K2B)

Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase Action of the cell.
This contribution might be especially significant in plasma membrane, endosomal and Golgi compartments.

The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Gene Information

Human
Gene Name:	PI4K2B
Uniprot:	Q8TCG2
Entrez:	55300

Family

Belongs to:

PI3/PI4-kinase family

Alternative Names

EC 2.7.1.67; FLJ11105; phosphatidylinositol 4-kinase type 2 beta; phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta; phosphatidylinositol 4-kinase type-II beta; PI4KIIB; PI4KII-BETA; PIK42B

Molecular Weight

Mass (kDA):
54.744 kDA

Genomic Context


Human

Location:	4p15.2
Sequence:	4; NC_000004.12 (25234033..25279204)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm. Membrane. Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.

Diseases

Mental Disorders
Major Depressive Disorder
Depressive Disorder
Schizophrenia
Bipolar Disorder
Recurrent Major Depressive Episodes

PTMs

Phosphoprotein

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PI4K2B

References

PMID: 11923287 by Balla A., et al. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.

PMID: 12324459 by Wei Y.J., et al. Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.