Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A)

Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) into phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is needed for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) into phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the creation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

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