Hemogen Antibodies

AND HEMGN ELISA kits, Hemogen Proteins

Many biological assays use antibodies to detect Hemogen, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hemogen in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hemogen antibodies...

We validate the specificity of these antibodies to Hemogen by testing them on tissues known to express HEMGN positively and negatively. Browse below to find the HEMGN antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HEMGN Infographic by Boster Bio

All HEMGN Products

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Product

Figures

Specificity

Applications

Price

Hemogen (HEMGN) (NM_018437) Human Recombinant Protein

$1062
Cat # PROTQ9BXL5
20 µg

Anti-Hemogen (HEMGN) Mouse Monoclonal Antibody [Clone ID: OTI2D7]

Human

IHC, WB

$523
Cat # M08422
100 µl

Anti-HEMGN Antibody (C-term)

Human

$299
Cat # A08422
80 µl

Hemogen (HEMGN) (NM_018437) Human Over-expression Lysate

Human

$628
Cat # LS055363
100 µg

HEMGN Overview

Facts about Hemogen.

HEMGN 3D structure. Source: alphafold

Hemogen (HEMGN)

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model.

May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). .

Gene Information

Human
Gene Name:	HEMGN
Uniprot:	Q9BXL5
Entrez:	55363

Family

Belongs to:

No superfamily

Alternative Names

EDAGEDAG-1; Erythroid differentiation-associated gene protein; hemogen; Hemopoietic gene protein; NDR; Negative differentiation regulator protein

Molecular Weight

Mass (kDA):
55.341 kDA

Genomic Context


Human

Location:	9q22.33
Sequence:	9; NC_000009.12 (97926791..97944852, complement)

Tissue Specificity

Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.

Subcellular Localizations

Nucleus.

Diseases

Leukemia
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Neoplasms
Hematologic Neoplasms
Congenital Abnormality
Flt3 Internal Tandem Duplication
Cleft Palate
Hematopoietic Neoplasms
Acute Erythroblastic Leukemia

Tumor Angiogenesis
Malignant Neoplasms
Acute Leukemia
Cleft Lip
Dysequilibrium Syndrome

Interacting Proteins

CTBP1
NPM1

Pathways

Cell Proliferation
Cell Differentiation
Ribosome Biogenesis
Gene Silencing
Cell Cycle
Cell Growth
Centrosome Duplication
Angiogenesis

Rna Interference
Meiosis
Spermatogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HEMGN

References

PMID: 11404085 by Yang L.V., et al. Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms.

PMID: 14648837 by Yang L.V., et al. Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.