PHC1 Antibodies

AND PHC1 ELISA kits, PHC1 Proteins

Many biological assays use antibodies to detect PHC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHC1 antibodies...

We validate the specificity of these antibodies to PHC1 by testing them on tissues known to express PHC1 positively and negatively. Browse below to find the PHC1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHC1 Infographic by Boster Bio

All PHC1 Products

Product

Figures

Specificity

Applications

Price

Anti-Polyhomeotic-like protein 1 PHC1 Antibody

Human, Mouse, Rat

$405
Cat # A06437
100ul

PHC1 (NM_004426) Human Over-expression Lysate

Human

$960
Cat # LS001911
100 µg

Anti-PHC1 Antibody Picoband™

Human

ELISA, IF, ICC, WB

$370
Cat # A06437-3
100 µg/vial

PHC1 Overview

Facts about Polyhomeotic-like protein 1.

PHC1 3D structure. Source: alphafold

Polyhomeotic-like protein 1 (PHC1)

Part of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class necessary to keep the transcriptionally repressive state of several genes, such as Hox genes, throughout development. PcG PRC1 complex acts through chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.

Required for proper control of cellular levels of GMNN expression. .

Gene Information

Human
Gene Name:	PHC1
Uniprot:	P78364
Entrez:	1911

Family

Belongs to:

No superfamily

Alternative Names

early development regulator 1 (homolog of polyhomeotic 1); Early development regulatory protein 1; EDR1; HPH1; PH1; polyhomeotic homolog 1 (Drosophila); polyhomeotic-like 1 (Drosophila); polyhomeotic-like 1; polyhomeotic-like protein 1; RAE28

Molecular Weight

Mass (kDA):
105.534 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (8914509..8941467)

Subcellular Localizations

Nucleus.

Diseases

Carcinoma
Embryonal Carcinoma
Malignant Neoplasms
Neoplasms
Immunologic Deficiency Syndromes
Lymphoma
Malignant Paraganglionic Neoplasm
Growth Arrest
Cell Transformation, Neoplastic
Crest Syndrome
Burkitt Lymphoma
Adenoma
Malignant Neoplasm Of Brain

Hypoxia
Collagen Arthritis
X-linked Combined Immunodeficiency Diseases
Injury To Kidney
Primary Immune Deficiency Disorder
Pituitary Diseases
Pituitary Neoplasms

Interacting Proteins

BMI1
PCGF2
SFMBT2

Pathways

Gene Silencing
Cell Cycle
Pathogenesis
Prophase
Cell Differentiation
Localization
Cell Adhesion
Cell Activation
Stem Cell Differentiation
T Cell Activation
Cell Cycle Arrest
Chromatin Organization
Interphase

Segmentation
Meiosis
Mitotic Prophase
Gastrulation
Cell Proliferation
Mitosis
Segment Specification

PTMs

Methylation

Phosphorylation

Nitration

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHC1

References

PMID: 9121482 by Gunster M.J., et al. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.

PMID: 9199346 by Satijn D.P.E., et al. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.