PHC2 Antibodies

AND PHC2 ELISA kits, PHC2 Proteins

Many biological assays use antibodies to detect PHC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHC2 antibodies...

We validate the specificity of these antibodies to PHC2 by testing them on tissues known to express PHC2 positively and negatively. Browse below to find the PHC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHC2 Infographic by Boster Bio

All PHC2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Polyhomeotic-like protein 2 PHC2 Antibody

Human

$405
Cat # A06606
100ul

PHC2 (NM_004427) Human Over-expression Lysate

Human

$628
Cat # LS001912
100 µg

PHC2 Overview

Facts about Polyhomeotic-like protein 2.

PHC2 3D structure. Source: alphafold

Polyhomeotic-like protein 2 (PHC2)

Part of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex course necessary to keep the transcriptionally repressive state of many genes, including Hox genes, during development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Information

Human
Gene Name:	PHC2
Uniprot:	Q8IXK0
Entrez:	1912

Family

Belongs to:

No superfamily

Alternative Names

early development regulator 2 (homolog of polyhomeotic 2); Early development regulatory protein 2; EDR2; HPH2; MGC163502; PH2; polyhomeotic 2; polyhomeotic homolog 2 (Drosophila); polyhomeotic-like 2 (Drosophila); polyhomeotic-like 2; polyhomeotic-like protein 2

Molecular Weight

Mass (kDA):
90.713 kDA

Genomic Context


Human

Location:	1p35.1
Sequence:	1; NC_000001.11 (33323623..33375593, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Injury To Kidney
Epilepsy
Cell Transformation, Neoplastic
Nervousness
Neurodegenerative Disorders
Shock, Hemorrhagic

Status Epilepticus
Acute Kidney Injury

Pathways

Cell Proliferation
Localization
Methylation
Peyer's Patch Development
Dna Repair
Dna Methylation
Histone H2b Ubiquitination
Senescence
Translation
Cell Cycle

Prophase
Pachytene
Histone Methylation
Rna Interference
Histone H2a Ubiquitination

PTMs

Ubiquitination

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHC2

References

PMID: 12384788 by Tonkin E., et al. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family.

PMID: 10976766 by Gunther M., et al. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.