PARL Antibodies

AND PARL ELISA kits, PARL Proteins

Many biological assays use antibodies to detect PARL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARL antibodies...

We validate the specificity of these antibodies to PARL by testing them on tissues known to express PARL positively and negatively. Browse below to find the PARL antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PARL Infographic by Boster Bio

All PARL Products

Product

Figures

Specificity

Applications

Price

Anti-PARL Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A08686
0.1 mg

Anti-PARL Monoclonal Antibody

Human

ELISA, WB

$380
Cat # M08686
100ul

PARL (NM_018622) Human Over-expression Lysate

Human

$628
Cat # LS055486
100 µg

PARL Overview

Facts about Presenilins-associated rhomboid-like protein, mitochondrial.

PARL 3D structure. Source: alphafold

Presenilins-associated rhomboid-like protein, mitochondrial (PARL)

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic type of OPA1 which prevents the release of mitochondrial cytochrome c in response to inherent apoptoptic signals (By similarity).

Promotes changes in mitochondria morphology controlled by phosphorylation of P-beta domain. .

Gene Information

Human
Gene Name:	PARL
Uniprot:	Q9H300
Entrez:	55486

Family

Belongs to:

peptidase S54 family

Alternative Names

EC 3.4.21.105; mitochondrial; PARL; presenilin associated, rhomboid-like; PRO2207; PSARL1; RHBDS1; rhomboid 7 homolog 1

Molecular Weight

Mass (kDA):
42.19 kDA

Genomic Context


Human

Location:	3q27.1
Sequence:	3; NC_000003.12 (183826488..183884901, complement)

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein.; [P-beta]: Nucleus. Translocated into the nucleus by an unknown mechanism (PubMed:17116872).

Diseases

Parkinson Disease
Optic Atrophy
Atrophy
Insulin Resistance
Optic Atrophy, Autosomal Dominant
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Plant Diseases
Nerve Degeneration
Glaucoma, Open-angle
Glaucoma
Blind Vision

Neurodegenerative Disorders
Disorder Of The Optic Nerve
Optic Atrophy, Hereditary, Leber
Cholangiocarcinoma
Malnutrition
Diabetic Nephropathy
Malignant Neoplasm Of Breast

Pathways

Proteolysis
Cell Death
Mitochondrial Fusion
Pathogenesis
Transport
Programmed Cell Death
Aging
Photosynthesis
Oxidative Phosphorylation
Fermentation
Lactation
Membrane Fusion
Localization

Germination
Cell Adhesion
Quorum Sensing
Electron Transport
Electron Transport Chain
Regulation Of Cytoskeleton
Regulation Of Mitochondrial Fusion

PTMs

Cleavage

Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARL

References

PMID: 12214059 by Pellegrini L., et al. PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of presenilin-1 and -2.

PMID: 14732705 by Sik A., et al. Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide.