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- Table of Contents
Facts about Carbohydrate sulfotransferase 12.
Activity toward partially desulfated dermatan sulfate is however lower. Doesn't form 4, 6-di-O-sulfated GalNAc if chondroitin sulfate C is used as an acceptor.
Human | |
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Gene Name: | CHST12 |
Uniprot: | Q9NRB3 |
Entrez: | 55501 |
Belongs to: |
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sulfotransferase 2 family |
C4S-2; C4ST2C4ST-2; carbohydrate (chondroitin 4) sulfotransferase 12; carbohydrate sulfotransferase 12; Chondroitin 4-O-sulfotransferase 2; Chondroitin 4-sulfotransferase 2; EC 2.8.2.5; Sulfotransferase Hlo
Mass (kDA):
48.414 kDA
Human | |
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Location: | 7p22.3 |
Sequence: | 7; NC_000007.14 (2403489..2448484) |
Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 10781601 by Hiraoka N., et al. Molecular cloning and expression of two distinct human chondroitin 4- O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.
PMID: 12847091 by Mikami T., et al. Specificities of three distinct human chondroitin/dermatan N- acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor. Implication of differential roles in dermatan sulfate biosynthesis.