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PAF1 Antibodies
AND PAF1 ELISA kits, PAF1 Proteins
Many biological assays use antibodies to detect PAF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAF1 antibodies...
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PAF1 Overview
Facts about RNA polymerase II-associated factor 1 homolog.
RNA polymerase II-associated factor 1 homolog (PAF1)
Component of the PAF1 complex (PAF1C) that has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and'Ser-2'- and'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in collaboration with the DSIF complex and HTATSF1.
PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAF1 |
| Uniprot: | Q8N7H5 |
| Entrez: | 54623 |
Family
| Belongs to: |
|---|
| PAF1 family |
Alternative Names
F23149_1; FLJ11123; Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae); Pancreatic differentiation protein 2; PD2hPAF1; RNA polymerase II-associated factor 1 homolog
Molecular Weight
Mass (kDA):
59.976 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (39385629..39391106, complement) |
Subcellular Localizations
Nucleus. Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Diseases
- Neoplasms
- Malignant Neoplasms
- Hyperparathyroidism-jaw Tumor Syndrome
- Parathyroid Gland Adenocarcinoma
- Cell Transformation, Neoplastic
- Carcinoma
- Leukemia
- Parathyroid Neoplasms
- Jaw Neoplasms
- Hyperparathyroidism 3
- Hereditary Malignant Neoplasm
- Fibrolamellar Carcinoma
Interacting Proteins
- CDC73
- CTR9
- FXR2
- HSPB1
- KMT2A
- LEO1
- POLR2A
- RTF1
- TCEA1
- TTC37
Pathways
- Methylation
- Cell Cycle
- Histone Methylation
- Histone Modification
- Chromatin Remodeling
- Localization
- Cell Growth
- Rna Processing
- Rna Interference
- Cell Proliferation
- Cell Cycle Arrest
- Histone H2b Ubiquitination
- Histone Monoubiquitination
PTMs
- Methylation
- Phosphorylation
- Ubiquitination
- Cleavage
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAF1
bosterbio.com/bosterbio-gene-info-cards/PAF1
References
PMID: 16491129 by Moniaux N., et al. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
PMID: 16024656 by Zhu B., et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis.