Prolyl 3-hydroxylase 2 Antibodies

AND P3H2 ELISA kits, Prolyl 3-hydroxylase 2 Proteins

Many biological assays use antibodies to detect Prolyl 3-hydroxylase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prolyl 3-hydroxylase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prolyl 3-hydroxylase 2 antibodies...

We validate the specificity of these antibodies to Prolyl 3-hydroxylase 2 by testing them on tissues known to express P3H2 positively and negatively. Browse below to find the P3H2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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P3H2 Infographic by Boster Bio

All P3H2 Products

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Anti-LEPREL1 P3H2 Antibody

Human, Mouse, Rat

$405
Cat # A09235
100ul

Anti-P3H2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A09235-1
100 μg/vial

P3H2 Overview

Facts about Prolyl 3-hydroxylase 2.

P3H2 3D structure. Source: alphafold

Prolyl 3-hydroxylase 2 (P3H2)

Prolyl 3-hydroxylase that catalyzes the post- translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and at the eye lens capsule (By similarity).

Has high activity with the type IV collagen COL4A1, and reduced activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197).

Gene Information

Human
Gene Name:	P3H2
Uniprot:	Q8IVL5
Entrez:	55214

Family

Belongs to:

leprecan family

Alternative Names

Prolyl 3-hydroxylase 2

Molecular Weight

Mass (kDA):
80.984 kDA

Genomic Context


Human

Location:	3q28
Sequence:	3; NC_000003.12 (189956728..190122437, complement)

Tissue Specificity

Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells (at protein level) (PubMed:15063763). Expressed in adult heart, placenta, lung, liver, skeletal muscle and kidney (PubMed:15063763, PubMed:18487197). Detected in fetal heart, spleen, lung, liver skeletal muscle and kidney (PubMed:18487197).

Subcellular Localizations

Endoplasmic reticulum. Sarcoplasmic reticulum. Golgi apparatus.

Diseases

Myopia, high, with cataract and vitreoretinal degeneration (MCVD)

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P3H2

References

PMID: 10449603 by Thelin-Jaernum S., et al. Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas.

PMID: 15063763 by Jaernum S., et al. LEPREL1, a novel ER and Golgi resident member of the Leprecan family.