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- Table of Contents
Facts about OCIA domain-containing protein 1.
May act as a scaffold, raising STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).
Human | |
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Gene Name: | OCIAD1 |
Uniprot: | Q9NX40 |
Entrez: | 54940 |
Belongs to: |
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OCIAD1 family |
Asrij; MGC111072; OCIA domain containing 1; OCIA domain-containing protein 1; OCIAFLJ20455; Ovarian carcinoma immunoreactive antigen; TPA018
Mass (kDA):
27.626 kDA
Human | |
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Location: | 4p11 |
Sequence: | 4; NC_000004.12 (48830924..48861817) |
Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord.
Endosome.
PMID: 11162530 by Luo L.Y., et al. Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library.
PMID: 20515946 by Wang C., et al. Role of the 18:1 lysophosphatidic acid-ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1)-integrin axis in generating late- stage ovarian cancer.