RNF125 Antibodies

AND RNF125 ELISA kits, RNF125 Proteins

Many biological assays use antibodies to detect RNF125, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF125 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF125 antibodies...

We validate the specificity of these antibodies to RNF125 by testing them on tissues known to express RNF125 positively and negatively. Browse below to find the RNF125 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF125 Infographic by Boster Bio

All RNF125 Products

Product

Figures

Specificity

Applications

Price

Anti-RNF125 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30664
100ul

Anti-TRAC-1 RNF125 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A08878
100ul

RNF125 (NM_017831) Human Over-expression Lysate

Human

$628
Cat # LS054941
100 µg

RNF125 Overview

Facts about E3 ubiquitin-protein ligase RNF125.

RNF125 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNF125 (RNF125)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I in'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729).

Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934).

Gene Information

Human
Gene Name:	RNF125
Uniprot:	Q96EQ8
Entrez:	54941

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase RNF125; EC 6.3.2.-; FLJ20456; MGC21737; ring finger protein 125TRAC1; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1

Molecular Weight

Mass (kDA):
26.454 kDA

Genomic Context


Human

Location:	18q12.1
Sequence:	18; NC_000018.10 (32018585..32090756)

Tissue Specificity

Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.

Subcellular Localizations

Golgi apparatus membrane; Lipid-anchor. Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.