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Nlrp6 Antibodies
AND Nlrp6 ELISA kits, Nlrp6 Proteins
Many biological assays use antibodies to detect Nlrp6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nlrp6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nlrp6 antibodies...
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Nlrp6 Overview
Facts about NACHT, LRR and PYD domains-containing protein 6.
NACHT, LRR and PYD domains-containing protein 6 (Nlrp6)
As the sensor part of this NLRP6 inflammasome, plays an essential role in innate immunity and inflammation. In response to yet unidentified signals, initiates the creation of the inflammasome polymeric complex, made from NLRP6, PYCARD and CASP1 (or possibly CASP4/CASP11).
Recruitment of proCASP1 into the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:21593405).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Nlrp6 |
| Uniprot: | Q91WS2 |
| Entrez: | 101613 |
Family
| Belongs to: |
|---|
| NLRP family |
Alternative Names
Angiotensin II/Vasopressin Receptor; AVR; CLR11.4; NACHT, Leucine Rich Repeat And PYD Containing 6; NACHT, LRR And PYD Containing Protein 6; NACHT, LRR And PYD Domains-Containing Protein 6; NALP6; NAVR; NAVR/AVR; NLR Family, Pyrin Domain Containing 6; NLRP6 ; NLRP6; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 6; PAN3; PYPAF5; PYRIN-Containing APAF1-Like Protein 5
Molecular Weight
Mass (kDA):
97.402 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7|7 F5 |
| Sequence: | 7; |
Tissue Specificity
Highly expressed in the gastrointestinal tract, predominantly in colonic myofibroblasts and in colonic epithelial and endothelial cells. Within the intestinal mucosa, highly expressed by goblet cells. Also expressed in hepatocytes and in immune cells, including CD4(+) and CD8(+) T-cells, dendritic cells, mastocytes and peritoneal macrophages, as well as in lung, kidney, bladder and gonads.
Diseases
- Inflammation
- Colitis
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Melanoma
- Neoplasms
- Infective Disorder
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Bacterial Infections
- Metabolic Diseases
- Liver Diseases
Pathways
- Secretion
- Cell Death
- Pathogenesis
- Wound Healing
- Pyroptosis
- Regeneration
- Cell Proliferation
- Virulence
Research Areas
- Immunology
- Inflammation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nlrp6
bosterbio.com/bosterbio-gene-info-cards/Nlrp6
References
PMID: 20923861 by Herrera V.L., et al. AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice.
PMID: 21593405 by Normand S., et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury.