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- Table of Contents
Facts about Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase.
Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no action toward native proteins.
Human | |
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Gene Name: | NGLY1 |
Uniprot: | Q96IV0 |
Entrez: | 55768 |
Belongs to: |
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transglutaminase-like superfamily |
EC 3.5.1.52; hPNGase; N-glycanase 1FLJ12409; peptide:N-glycanase; peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; PNG1FLJ11005; PNGase
Mass (kDA):
74.39 kDA
Human | |
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Location: | 3p24.2 |
Sequence: | 3; NC_000003.12 (25718944..25790039, complement) |
Cytoplasm.
PMID: 10831608 by Suzuki T., et al. PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase.
PMID: 15362974 by McNeill H., et al. A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.