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- Table of Contents
Facts about Serine/threonine-protein kinase Nek8.
May regulate ciliary biogenesis through targeting of proteins into the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Mouse | |
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Gene Name: | Nek8 |
Uniprot: | Q91ZR4 |
Entrez: | 140859 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; EC 2.7.11.1; JCKNIMA-related kinase 12a; MGC138445; NEK12A; nephrocystin 9; Never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; Nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9NIMA-family kinase NEK8; serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
Mass (kDA):
75.265 kDA
Mouse | |
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Location: | 11 B5|11 46.74 cM |
Sequence: | 11; |
Kidney, liver, and testis.
PMID: 12421721 by Liu S., et al. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.
PMID: 16267153 by Mahjoub M.R., et al. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes.