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MYSM1 Antibodies
AND MYSM1 ELISA kits, MYSM1 Proteins
Many biological assays use antibodies to detect MYSM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MYSM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MYSM1 antibodies...
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MYSM1 Overview
Facts about Histone H2A deubiquitinase MYSM1.
Histone H2A deubiquitinase MYSM1 (MYSM1)
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a particular tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes.
Deubiquitination of histone H2A contributes to ease the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by engaging in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYSM1 |
| Uniprot: | Q5VVJ2 |
| Entrez: | 114803 |
Family
| Belongs to: |
|---|
| peptidase M67A family |
Alternative Names
2A-DUB; DKFZp779J1554; DKFZp779J1721,2A-DUB; Histone H2A Deubiquitinase MYSM1; KIAA1915; Myb-like, SWIRM and MPN domains 1,2ADUB; MYSM1; RP4-592A1.1; SWIRM and MPN domain-containing protein 1
Molecular Weight
Mass (kDA):
95.032 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p32.1 |
| Sequence: | 1; NC_000001.11 (58654739..58700091, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Myeloproliferative Disease
- Diabetes Mellitus, Non-insulin-dependent
- Tumor Angiogenesis
- Diabetic Retinopathy
- Neoplasms
- Anemia
- Lymphopenia
- Retinal Diseases
Pathways
- Cell Development
- Gene Silencing
- Stem Cell Differentiation
- Histone Acetylation
- Cell Differentiation
- Angiogenesis
- Chromatin Modification
- Pathogenesis
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYSM1
bosterbio.com/bosterbio-gene-info-cards/MYSM1
References
PMID: 17707232 by Zhu P., et al. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
PMID: 24288411 by Alsultan A., et al. MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK- and B-cell counts.