M-phase phosphoprotein 8 Antibodies

AND MPHOSPH8 ELISA kits, M-phase phosphoprotein 8 Proteins

Many biological assays use antibodies to detect M-phase phosphoprotein 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with M-phase phosphoprotein 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop M-phase phosphoprotein 8 antibodies...

We validate the specificity of these antibodies to M-phase phosphoprotein 8 by testing them on tissues known to express MPHOSPH8 positively and negatively. Browse below to find the MPHOSPH8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MPHOSPH8 Infographic by Boster Bio

All MPHOSPH8 Products

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Product

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Specificity

Applications

Price

Anti-MPP8 MPHOSPH8 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A11685
100ul

MPP8 (MPHOSPH8) (NM_017520) Human Over-expression Lysate

Human

$628
Cat # LS054737
100 µg

MPHOSPH8 Overview

Facts about M-phase phosphoprotein 8.

MPHOSPH8 3D structure. Source: alphafold

M-phase phosphoprotein 8 (MPHOSPH8)

Heterochromatin component that specifically recognizes and binds methylated'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci full of H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416).

Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the receptor (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).

Gene Information

Human
Gene Name:	MPHOSPH8
Uniprot:	Q99549
Entrez:	54737

Family

Belongs to:

No superfamily

Alternative Names

FLJ35237; HSMPP8; M-phase phosphoprotein 8; M-phase phosphoprotein, mpp; M-phase phosphoprotein, mpp8; mpp8; TWA3; Two hybrid-associated protein 3 with RanBPM

Molecular Weight

Mass (kDA):
97.182 kDA

Genomic Context


Human

Location:	13q12.11
Sequence:	13; NC_000013.11 (19633648..19673441)

Subcellular Localizations

Nucleus. Chromosome. Detected on heterochromatin (PubMed:20871592, PubMed:26022416). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (PubMed:20871592).

Interacting Proteins

EHMT1
FAM208A
HIST1H3A
SETDB1

PTMs

Acetylation

Phosphoprotein

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPHOSPH8

References

PMID: 8885239 by Matsumoto-Taniura N., et al. Identification of novel M phase phosphoproteins by expression cloning.

PMID: 12559565 by Umeda M., et al. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.