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- Table of Contents
Facts about Protein FEV.
Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell development.
Human | |
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Gene Name: | FEV |
Uniprot: | Q99581 |
Entrez: | 54738 |
Belongs to: |
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ETS family |
FEV (ETS oncogene family); FEV (fifth Ewing variant); Fifth Ewing variant protein; HSRNAFEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; PET1; Pet-1; protein FEV
Mass (kDA):
25.03 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (218981087..218985184, complement) |
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
Nucleus.
PMID: 9121764 by Peter M., et al. A new member of the ETS family fused to EWS in Ewing tumors.
PMID: 12761502 by Maurer P., et al. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain.