METTL14 Antibodies

AND METTL14 ELISA kits, METTL14 Proteins

Many biological assays use antibodies to detect METTL14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with METTL14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop METTL14 antibodies...

We validate the specificity of these antibodies to METTL14 by testing them on tissues known to express METTL14 positively and negatively. Browse below to find the METTL14 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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METTL14 Infographic by Boster Bio

All METTL14 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-METTL14 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A07389-2
100 μg/vial

Anti-METTL14 Antibody (N-Term)

Human, Mouse

IF, IHC-P, WB

$299
Cat # M07389
50 µl

METTL14 (NM_020961) Human Over-expression Lysate

Human

$628
Cat # LS057721
100 µg

METTL14 Overview

Facts about N6-adenosine-methyltransferase non-catalytic subunit.

N6-adenosine-methyltransferase non-catalytic subunit (METTL14)

The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and modulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA- binding scaffold that recognizes the substrate as opposed to the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140).

N6-methyladenosine (m6A), which occurs at the 5'-[AG]GAC-3' consensus websites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity).

Gene Information

Human
Gene Name:	METTL14
Uniprot:	Q9HCE5
Entrez:	57721

Family

Belongs to:

MT-A70-like family

Alternative Names

EC 2.1.1; EC 2.1.1.-; KIAA1627; KIAA1627methyltransferase-like protein 14; methyltransferase like 14; METTL14

Molecular Weight

Mass (kDA):
52.15 kDA

Genomic Context


Human

Location:	4q26
Sequence:	4; NC_000004.12 (118685375..118715430)

Subcellular Localizations

Nucleus.

Diseases

Neoplasms

Interacting Proteins

METTL3

Pathways

Cell Proliferation
Regulation Of Cell Proliferation

PTMs

Phosphoprotein

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/METTL14

References

PMID: 24407421 by Ping X.L., et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

PMID: 24981863 by Schwartz S., et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.