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- Table of Contents
Facts about Target of rapamycin complex 2 subunit MAPKAP1.
MTORC2 seems to work upstream of Rho GTPases to regulate the actin cytoskeleton, probably by triggering one or more Rho-type guanine nucleotide exchange factors. MTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
Human | |
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Gene Name: | MAPKAP1 |
Uniprot: | Q9BPZ7 |
Entrez: | 79109 |
Belongs to: |
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SIN1 family |
JC310; MAPKAP1; MEKK2-interacting protein 1; MGC2745; MIP1; MIP1SIN1SIN1b; Mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; mSIN1; ras inhibitor MGC2745; SAPK-interacting protein 1; Sin1; SIN1g; stress-activated map kinase interacting protein 1; Stress-activated map kinase-interacting protein 1; stress-activated protein kinase-interacting 1; target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1
Mass (kDA):
59.123 kDA
Human | |
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Location: | 9q33.3 |
Sequence: | 9; NC_000009.12 (125437394..125707234, complement) |
Ubiquitously expressed, with highest levels in heart and skeletal muscle.
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
PMID: 15363842 by Schroder W., et al. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.
PMID: 15988011 by Cheng J., et al. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.