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MEPE Antibodies
AND MEPE ELISA kits, MEPE Proteins
Many biological assays use antibodies to detect MEPE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MEPE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MEPE antibodies...
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MEPE Overview
Facts about Matrix extracellular phosphoglycoprotein.
Matrix extracellular phosphoglycoprotein (MEPE)
Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095).
Regulates the mineralization of the extracellular matrix of the craniofacial complex, like teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070).
Gene Information
| Human | |
|---|---|
| Gene Name: | MEPE |
| Uniprot: | Q9NQ76 |
| Entrez: | 56955 |
Family
| Belongs to: |
|---|
| PF07175/osteoregulin family |
Alternative Names
extracellular phosphoglycoprotein with ASARM motif (bone); matrix extracellular phosphoglycoprotein; MEPE; OF45; Osteoregulin
Molecular Weight
Mass (kDA):
58.419 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (87821398..87846817) |
Tissue Specificity
Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058). Expressed by stem cells in dental pulp (PubMed:15153459). Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070). Expressed in teeth, specifically in decidious dentin (PubMed:20581062). Expressed in ondotoblasts (PubMed:12489176). Expressed in salivary glands (PubMed:15329369). Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762).
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Familial Hypophosphatemic Bone Disease
- Hypophosphatemia
- Osteomalacia
- Rickets
- Hypophosphatemic Rickets
- Neoplasms
- Oncogenic Osteomalacia
- Phosphate Diabetes
- Familial Hypophosphatemia
- Fracture
- Autosomal Dominant Hypophosphatemic Rickets
- Kidney Failure, Chronic
Interacting Proteins
- NCK1
Pathways
- Bone Mineralization
- Dentinogenesis
- Pathogenesis
- Excretion
- Regeneration
- Secretion
- Transport
- Ossification
- Cell Differentiation
- Bone Development
- Bone Resorption
- Osteoblast Differentiation
- Proteolysis
PTMs
- Cleavage
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEPE
bosterbio.com/bosterbio-gene-info-cards/MEPE
References
PMID: 10945470 by Rowe P.S.N., et al. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.
PMID: 11414762 by Argiro L., et al. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone.