LRRC8C Antibodies

AND LRRC8C ELISA kits, LRRC8C Proteins

Many biological assays use antibodies to detect LRRC8C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRRC8C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRRC8C antibodies...

We validate the specificity of these antibodies to LRRC8C by testing them on tissues known to express LRRC8C positively and negatively. Browse below to find the LRRC8C antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRRC8C Infographic by Boster Bio

All LRRC8C Products

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Specificity

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Price

LRRC8C (NM_032270) Human Recombinant Protein

$1249
Cat # PROTQ8TDW0
20 µg

LRRC8C (NM_032270) Human Over-expression Lysate

Human

$960
Cat # LS084230
100 µg

LRRC8C Overview

Facts about Volume-regulated anion channel subunit LRRC8C.

LRRC8C 3D structure. Source: alphafold

Volume-regulated anion channel subunit LRRC8C (LRRC8C)

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine.

Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. .

Gene Information

Human
Gene Name:	LRRC8C
Uniprot:	Q8TDW0
Entrez:	84230

Family

Belongs to:

LRRC8 family

Alternative Names

AD158; DKFZp586J1119; factor for adipocyte differentiation 158; FAD158; leucine rich repeat containing 8 family, member C; leucine rich repeat containing 8C; leucine-rich repeat-containing protein 8C

Molecular Weight

Mass (kDA):
92.45 kDA

Genomic Context


Human

Location:	1p22.2
Sequence:	1; NC_000001.11 (89615810..89719533)

Tissue Specificity

Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane.

Interacting Proteins

LRRC8A

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRRC8C

References

PMID: 15564382 by Tominaga K., et al. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation.

PMID: 22532330 by Abascal F., et al. LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.