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- Table of Contents
Facts about E3 ubiquitin-protein ligase TRAF7.
Induces apoptosis when overexpressed. .
Human | |
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Gene Name: | TRAF7 |
Uniprot: | Q6Q0C0 |
Entrez: | 84231 |
Belongs to: |
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WD repeat TRAF7 family |
DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; EC 6.3.2.-; MGC7807; RFWD1RING finger protein 119; RNF119RING finger and WD repeat-containing protein 1; TNF receptor-associated factor 7ring finger and WD repeat domain 1
Mass (kDA):
74.609 kDA
Human | |
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Location: | 16p13.3 |
Sequence: | 16; NC_000016.10 (2155778..2178129) |
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Cytoplasmic vesicle. Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
PMID: 15001576 by Xu L.-G., et al. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
PMID: 14743216 by Bouwmeester T., et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.