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- Table of Contents
Facts about Leucine-rich repeat-containing G-protein coupled receptor 4.
In contrast to classical G-protein coupled receptors, doesn't activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is necessary for the growth of different organs, including liver, kidney, intestine, bone, reproductive tract and eye.
Human | |
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Gene Name: | LGR4 |
Uniprot: | Q9BXB1 |
Entrez: | 55366 |
Belongs to: |
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G-protein coupled receptor 1 family |
GPR48; GPR48G protein-coupled receptor 48; G-protein coupled receptor 48; leucine-rich repeat containing G protein-coupled receptor 4; Lgr4
Mass (kDA):
104.475 kDA
Human | |
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Location: | 11p14.1 |
Sequence: | 11; NC_000011.10 (27365961..27472790, complement) |
Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.
Cell membrane; Multi-pass membrane protein.
PMID: 11401528 by Loh E.D., et al. Molecular characterization of a novel glycoprotein hormone G-protein- coupled receptor.
PMID: 21909076 by Glinka A., et al. LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling.